尊敬的李医师：首先，是否已通过基因研究分析排除了可用来解释离子通道病变表型多样性或临床表现多样性的等位基因嵌和现象（发生在器官形成和胚胎分化阶段）。还有需要说明的一点是，一些等位基因更易在第八脑神经、左室、右室等部位出现，而其他部位的起搏细胞可完全正常。Richar-Ray/dba Richard Ray Jordan, M.D., SFM――Sergio Dubner 博士科委会主席Edgardo Schapachnik 博士组委会主席 44E RE: Asymptomatic patient with Brugada syndrome. Dr. Ray JordanDr. Li,Has genetic research analysis ruled out genetic allele chimerism (at thetime of organogenesis and embryological differentiation) to explain thephenotypic variety of channelopathies or numerous clinicalmanifestations? Another words are some alleles more likely to find orgravitate towards the eighth nerve, RV, vs LV etc., while otherregions of pacemaker cells remain entirely normal?Richar-Ray/dba Richard Ray Jordan, M.D., SFM--Dr. Sergi
