Objective To investigate the expression of HIF1α mRNA and protein at different time points of acute myocardial ischemia development and the effect of Simvastatin on the expression of HIF1α mRNA.
Methods The rat models of myocardial ischemia established by ligating the left coronary artery were to induce expression of HIF1α at different ischemia time. And rats were randomized to receive simvastatin pretreated 4 weeks before ischemia. The mRNA and protein products of HIF1α were detected by RT-PCR and immunohistochemical analysis, respectively. Results The HIF1α mRNA began to increase significantly at 0.5 hours, reached peak during 1-2 hours of ischemia, then lessened at 3 and 4 ho
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