Implantable Cardioverter Defibrillator Therapy in MADIT II Patients with Signs and Symptoms of Heart

Postinfarction patients with left ventricular dysfunction are at increased risk of mortality and sudden cardiac death. A decreased left ventricular ejection fraction (EF) remains the most effective predictor of mortality despite changing and improving clinical management of postinfarction patients. Over last two decades, numerous studies aiming to determine clinical usefulness of various pharmacologic and device strategies for preventing mortality in postinfarction patients used a decreased ejection fraction as the main criterion for patient enrollment. Multicenter Automatic Defibrillator Implantation Trial (MADIT), first primary prevention trial with implantable cardioverter defibrillator (ICD), used the combined risk stratification str

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