Nearly 5 million of americans are living with HF, and 550,000 new cases are diagnosed each year. Data from the Framingham Heart Study indicate that the incidence of congestive HF increases with age and is higher in men. The single most common etiology is coronary heart disease, but in a third of cases the etiology cannot be determined on the basis of non-invasive investigation alone. To be relevant to clinical practice, future clinical trials
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